Rational therapeutic approaches to progressive supranuclear palsy
Identifieur interne : 000440 ( Main/Exploration ); précédent : 000439; suivant : 000441Rational therapeutic approaches to progressive supranuclear palsy
Auteurs : Maria Stamelou [Allemagne] ; Rohan De Silva [Royaume-Uni] ; Oscar Arias-Carrin [Allemagne] ; Evangelia Boura [Allemagne] ; Matthias Hllerhage [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Ulrich Mller [Allemagne] ; Gnter U. Hglinger [Allemagne]Source :
- Brain [ 0006-8950 ] ; 2010-06.
Abstract
Progressive supranuclear palsy is a sporadic and progressive neurodegenerative disease, most often presenting as a symmetric, akinetic-rigid syndrome with postural instability, vertical supranuclear gaze palsy and frontal lobe deficits. It belongs to the family of tauopathies and involves both cortical and subcortical structures. Although the exact pathophysiology is not yet fully understood, several lines of evidence point to a crucial contribution from both genetic predisposition and mitochondrial dysfunction. Recently gained insights into the pathophysiology of this disease have led to several hypothesis-driven therapeutic approaches aiming at disease-modification rather than mere symptomatic neurotransmitter-replacement therapy. Agents targeting mitochondrial dysfunction have already shown a positive effect in a phase II study and further studies to verify and expand these results are ongoing. Clinical studies with agents targeting tau dysfunction such as tau-kinase inhibitors, tau-aggregation inhibitors and microtubule stabilizers are in preparation or ongoing. This review presents the current pathophysiological concepts driving these exciting therapeutic developments.
Url:
DOI: 10.1093/brain/awq115
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Rational therapeutic approaches to progressive supranuclear palsy</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name></author><author><name sortKey="De Silva, Rohan" sort="De Silva, Rohan" uniqKey="De Silva R" first="Rohan" last="De Silva">Rohan De Silva</name></author><author><name sortKey="Arias Carrin, Oscar" sort="Arias Carrin, Oscar" uniqKey="Arias Carrin O" first="Oscar" last="Arias-Carrin">Oscar Arias-Carrin</name></author><author><name sortKey="Boura, Evangelia" sort="Boura, Evangelia" uniqKey="Boura E" first="Evangelia" last="Boura">Evangelia Boura</name></author><author><name sortKey="Hllerhage, Matthias" sort="Hllerhage, Matthias" uniqKey="Hllerhage M" first="Matthias" last="Hllerhage">Matthias Hllerhage</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Mller, Ulrich" sort="Mller, Ulrich" uniqKey="Mller U" first="Ulrich" last="Mller">Ulrich Mller</name></author><author><name sortKey="Hglinger, Gnter U" sort="Hglinger, Gnter U" uniqKey="Hglinger G" first="Gnter U." last="Hglinger">Gnter U. Hglinger</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:383D5D807FEC7D515335A7F5CF1453A22258B12A</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1093/brain/awq115</idno><idno type="url">https://api.istex.fr/document/383D5D807FEC7D515335A7F5CF1453A22258B12A/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002A22</idno><idno type="wicri:Area/Main/Curation">002667</idno><idno type="wicri:Area/Main/Exploration">000440</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Rational therapeutic approaches to progressive supranuclear palsy</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>1 Department of Neurology, Philipps University, Marburg, D-35039</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="De Silva, Rohan" sort="De Silva, Rohan" uniqKey="De Silva R" first="Rohan" last="De Silva">Rohan De Silva</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>2 Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, WC1 N1PS</wicri:regionArea><wicri:noRegion>WC1 N1PS</wicri:noRegion></affiliation></author><author><name sortKey="Arias Carrin, Oscar" sort="Arias Carrin, Oscar" uniqKey="Arias Carrin O" first="Oscar" last="Arias-Carrin">Oscar Arias-Carrin</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>1 Department of Neurology, Philipps University, Marburg, D-35039</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Boura, Evangelia" sort="Boura, Evangelia" uniqKey="Boura E" first="Evangelia" last="Boura">Evangelia Boura</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>1 Department of Neurology, Philipps University, Marburg, D-35039</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Hllerhage, Matthias" sort="Hllerhage, Matthias" uniqKey="Hllerhage M" first="Matthias" last="Hllerhage">Matthias Hllerhage</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>1 Department of Neurology, Philipps University, Marburg, D-35039</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>1 Department of Neurology, Philipps University, Marburg, D-35039</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Mller, Ulrich" sort="Mller, Ulrich" uniqKey="Mller U" first="Ulrich" last="Mller">Ulrich Mller</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>3 Institut fr Humangenetik, Justus-Liebig-Universitt, Giessen, D-35392</wicri:regionArea><wicri:noRegion>35392</wicri:noRegion><wicri:noRegion>D-35392</wicri:noRegion></affiliation></author><author><name sortKey="Hglinger, Gnter U" sort="Hglinger, Gnter U" uniqKey="Hglinger G" first="Gnter U." last="Hglinger">Gnter U. Hglinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>1 Department of Neurology, Philipps University, Marburg, D-35039</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-06">2010-06</date><biblScope unit="volume">133</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1578">1578</biblScope><biblScope unit="page" to="1590">1590</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">383D5D807FEC7D515335A7F5CF1453A22258B12A</idno><idno type="DOI">10.1093/brain/awq115</idno><idno type="ArticleID">awq115</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Progressive supranuclear palsy is a sporadic and progressive neurodegenerative disease, most often presenting as a symmetric, akinetic-rigid syndrome with postural instability, vertical supranuclear gaze palsy and frontal lobe deficits. It belongs to the family of tauopathies and involves both cortical and subcortical structures. Although the exact pathophysiology is not yet fully understood, several lines of evidence point to a crucial contribution from both genetic predisposition and mitochondrial dysfunction. Recently gained insights into the pathophysiology of this disease have led to several hypothesis-driven therapeutic approaches aiming at disease-modification rather than mere symptomatic neurotransmitter-replacement therapy. Agents targeting mitochondrial dysfunction have already shown a positive effect in a phase II study and further studies to verify and expand these results are ongoing. Clinical studies with agents targeting tau dysfunction such as tau-kinase inhibitors, tau-aggregation inhibitors and microtubule stabilizers are in preparation or ongoing. This review presents the current pathophysiological concepts driving these exciting therapeutic developments.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name></region><name sortKey="Arias Carrin, Oscar" sort="Arias Carrin, Oscar" uniqKey="Arias Carrin O" first="Oscar" last="Arias-Carrin">Oscar Arias-Carrin</name><name sortKey="Boura, Evangelia" sort="Boura, Evangelia" uniqKey="Boura E" first="Evangelia" last="Boura">Evangelia Boura</name><name sortKey="Hglinger, Gnter U" sort="Hglinger, Gnter U" uniqKey="Hglinger G" first="Gnter U." last="Hglinger">Gnter U. Hglinger</name><name sortKey="Hglinger, Gnter U" sort="Hglinger, Gnter U" uniqKey="Hglinger G" first="Gnter U." last="Hglinger">Gnter U. Hglinger</name><name sortKey="Hllerhage, Matthias" sort="Hllerhage, Matthias" uniqKey="Hllerhage M" first="Matthias" last="Hllerhage">Matthias Hllerhage</name><name sortKey="Mller, Ulrich" sort="Mller, Ulrich" uniqKey="Mller U" first="Ulrich" last="Mller">Ulrich Mller</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name></country><country name="Royaume-Uni"><noRegion><name sortKey="De Silva, Rohan" sort="De Silva, Rohan" uniqKey="De Silva R" first="Rohan" last="De Silva">Rohan De Silva</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000440 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000440 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:383D5D807FEC7D515335A7F5CF1453A22258B12A
|texte= Rational therapeutic approaches to progressive supranuclear palsy
}}
| This area was generated with Dilib version V0.6.23. |  |